Transfusion Strategy for Acute Brain Injury

To the Editor The recently published TRAIN randomized clinical trial provided new evidence that a liberal transfusion strategy with a hemoglobin threshold of 9 g/dL significantly improved neurological outcomes at 180 days compared with a restrictive strategy with a threshold of 7 g/dL in patients with acute brain injury. Although the comparison between the TRAIN trial and the HEMOTION trial has already been well documented, we would like to highlight a previously unnoted major difference between these 2 trials, the treatment duration.