The RENOVATE Trial
Hypoxemic acute respiratory failure denotes oxygenation failure attributable to various mechanisms, including ventilation-perfusion mismatch, increased shunt, diffusion impairment, and alveolar hypoventilation. The most common etiology of hypoxemic acute respiratory failure is pneumonia. A definition of hypoxemic acute respiratory failure was recently proposed, emphasizing signs of respiratory distress and Pao2 level less than 60 mm Hg in room air or level of Pao2:Fio2 (fraction of inspired oxygen) less than 300 under oxygen. By contrast, hypercapnic acute respiratory failure is characterized by ventilation failure defined by respiratory acidosis (pH level ≤7.35 with Paco2 >45 mm Hg) and is mainly caused by exacerbation of chronic obstructive pulmonary disease (COPD).
Hypoxemic acute respiratory failure denotes oxygenation failure attributable to various mechanisms, including ventilation-perfusion mismatch, increased shunt, diffusion impairment, and alveolar hypoventilation. The most common etiology of hypoxemic acute respiratory failure is pneumonia. A definition of hypoxemic acute respiratory failure was recently proposed, emphasizing signs of respiratory distress and Pao2 level less than 60 mm Hg in room air or level of Pao2:Fio2 (fraction of inspired oxygen) less than 300 under oxygen. By contrast, hypercapnic acute respiratory failure is characterized by ventilation failure defined by respiratory acidosis (pH level ≤7.35 with Paco2 >45 mm Hg) and is mainly caused by exacerbation of chronic obstructive pulmonary disease (COPD).
