Researchers identify potential MASH target after gene disruption triggers liver symptoms in mice

Researchers at Waseda University in Japan have identified a gene that, when rendered nonfunctional in mice, causes the rodents to develop telltale signs of the liver disease metabolic dysfunction-associated steatohepatitis (MASH). The result suggests that the protein made by the gene, known as Nwd1, and other molecules it interacts with could be worthwhile targets for new MASH therapies.

Mar 13, 2025 - 23:23
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Researchers identify potential MASH target after gene disruption triggers liver symptoms in mice
Researchers at Waseda University in Japan have identified a gene that, when rendered nonfunctional in mice, causes the rodents to develop telltale signs of the liver disease metabolic dysfunction-associated steatohepatitis (MASH). The result suggests that the protein made by the gene, known as Nwd1, and other molecules it interacts with could be worthwhile targets for new MASH therapies.