Interpenetrating Polymer Network Hydrogels with Tunable Viscoelasticity and Proteolytic Cleavability to Direct Stem Cells In Vitro (Adv. Healthcare Mater. 9/2025)
Advanced Healthcare Materials, Volume 14, Issue 9, April 4, 2025.
Viscoelastic sGAG-Hydrogels
In article 2402656, Carsten Werner and co-workers introduce a sulfated glycosaminoglycan (sGAG)-based interpenetrating polymer network hydrogel platform with tunable viscoelasticity, stiffness, and proteolytic cleavability. This platform enables the detailed study of stem cell morphogenesis, showing improved cell spreading and YAP activation in human mesenchymal stem cells, and modified morphogenesis in human induced pluripotent stem cell cysts.
