Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery
To the Editor We read with interest the SIRAKI02 trial by Dr Pérez-Fernández and colleagues, which was recently published in JAMA. They report a reduction in acute kidney injury (AKI) when using an extracorporeal blood purification (EBP) device during nonemergent cardiac surgery that required cardiopulmonary bypass. The purification column used in this study was proposed to reduce AKI risk via removal of intraoperative inflammatory cytokines and damage-associated molecular patterns, such as free hemoglobin. The reduction of inflammatory cytokines was supported by a reported reduction in circulating tumor necrosis factor α and interleukin 8 in the EBP group compared with the control group.
To the Editor We read with interest the SIRAKI02 trial by Dr Pérez-Fernández and colleagues, which was recently published in JAMA. They report a reduction in acute kidney injury (AKI) when using an extracorporeal blood purification (EBP) device during nonemergent cardiac surgery that required cardiopulmonary bypass. The purification column used in this study was proposed to reduce AKI risk via removal of intraoperative inflammatory cytokines and damage-associated molecular patterns, such as free hemoglobin. The reduction of inflammatory cytokines was supported by a reported reduction in circulating tumor necrosis factor α and interleukin 8 in the EBP group compared with the control group.
