Multiscale Thermal Analysis of Gold Nanostars in 3D Tumor Spheroids: Integrating Cellular‐Level Photothermal Effects and Nanothermometry via X‐Ray Spectroscopy (Adv. Healthcare Mater. 11/2025)

Nanothermal Therapy

In article 2403799 Claire Wilhelm, Álvaro Muñoz-Noval, Ana Espinosa, and co-workers investigate nanoscale temperatures generated by photoexcited gold nanostars and their correlation with microscale thermal damage at the cellular level. Using X-ray absorption spectroscopy and confocal microscopy in 3D cancer spheroids, it assesses localized heating effects and examines tumor cell structure and integrity, offering insights into their potential for precise cancer treatment.