Intrinsic electrical activity drives small-cell lung cancer progression
Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08575-7Electrical excitability in neuroendocrine SCLC cells promotes tumour progression through action potential firing, increasing ATP demand and oxidative phosphorylation dependency, whereas non-neuroendocrine cells provide metabolic support, driving a tumour-autonomous cycle that enhances tumorigenesis and metastasis.
Nature, Published online: 12 February 2025; doi:10.1038/s41586-024-08575-7Electrical excitability in neuroendocrine SCLC cells promotes tumour progression through action potential firing, increasing ATP demand and oxidative phosphorylation dependency, whereas non-neuroendocrine cells provide metabolic support, driving a tumour-autonomous cycle that enhances tumorigenesis and metastasis.
