Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

Nature, Published online: 09 April 2025; doi:10.1038/s41586-025-08852-zThe immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

Apr 9, 2025 - 16:36
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Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

Nature, Published online: 09 April 2025; doi:10.1038/s41586-025-08852-zThe immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.