Comprehensive interrogation of synthetic lethality in the DNA damage response
Nature, Published online: 09 April 2025; doi:10.1038/s41586-025-08815-4Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in preventing under-replication and SMARCAL1 and FANCM in remodelling persistent cruciform DNA structures.
Nature, Published online: 09 April 2025; doi:10.1038/s41586-025-08815-4Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in preventing under-replication and SMARCAL1 and FANCM in remodelling persistent cruciform DNA structures.
