Combination Drug Therapy May Better Alleviate PTSD Symptoms Than SSRIs Alone

Currently, the only medications approved by the US Food and Drug Administration for posttraumatic stress disorder (PTSD) are the selective serotonin reuptake inhibitors (SSRIs) sertraline and paroxetine. But a 2022 meta-analysis of drugs used for PTSD found that about 40% of patients don’t benefit from SSRIs. However, those living with PTSD who took a combination of sertraline and the antipsychotic brexpiprazole showed greater improvements in symptoms than those who took sertraline with a placebo.