RNA codon expansion via programmable pseudouridine editing and decoding
Nature, Published online: 25 June 2025; doi:10.1038/s41586-025-09165-xAn RNA codon-expansion strategy enables incorporation of non-canonical amino acids into proteins of interest orthogonally to existing methods by inserting pseudouridine codons into specific mRNA transcripts and using an engineered decoder tRNA.
Nature, Published online: 25 June 2025; doi:10.1038/s41586-025-09165-xAn RNA codon-expansion strategy enables incorporation of non-canonical amino acids into proteins of interest orthogonally to existing methods by inserting pseudouridine codons into specific mRNA transcripts and using an engineered decoder tRNA.
