Plasticity of the mammalian integrated stress response
Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08794-6A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 axis, enabling metabolic reprogramming.
Nature, Published online: 26 March 2025; doi:10.1038/s41586-025-08794-6A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 axis, enabling metabolic reprogramming.
