Plant Polyphenol‐Based Injectable Hydrogels: Advances and Biomedical Applications

Plant polyphenol-based injectable hydrogels exhibit a diverse range of properties, making them highly versatile for biomedical applications. These hydrogels exhibit characteristics such as self-healing, shear thinning behavior, strong wet adhesion, high mechanical strength, low swelling ratios, and responsiveness to external stimuli. Their multifunctionality has positioned them as valuable tools in drug delivery systems, biosensor technologies, anticancer therapies, and other applications.

Abstract

Plant polyphenol-based hydrogels, known for their biocompatibility and adhesive properties, have emerged as promising materials in biomedical applications. These hydrogels leverage the catechol group's ability to form stable bonds in moist environments, similar to mussel adhesive proteins. This review provides a comprehensive overview of their synthesis, adhesion mechanisms, and applications, particularly in wound healing, tissue regeneration, and drug delivery. However, challenges related to in vivo stability and long-term biocompatibility remain critical barriers to clinical translation. Future research should focus on enhancing the bioactivity, biocompatibility, and scalability of these hydrogels, while addressing concerns related to toxicity, immune responses, and large-scale manufacturing. Advances in artificial intelligence-assisted screening and 3D/4D bioprinting are expected to accelerate their development and clinical translation. Furthermore, the integration of biomimetic designs and responsive functionalities, such as pH or temperature sensitivity, holds promise for further improving their therapeutic efficacy. In conclusion, the development of multifunctional plant polyphenol-based hydrogels represents a promising frontier in advancing personalized medicine and minimally invasive treatments.