Metformin reduces the competitive advantage of <i>Dnmt3a</i><sup>R878H</sup> HSPCs
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08871-wDnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal haematopoiesis and a potential therapeutic target.
Nature, Published online: 16 April 2025; doi:10.1038/s41586-025-08871-wDnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal haematopoiesis and a potential therapeutic target.
