The aging ovary stands on the shoulders of giant multinucleated cells

by Avery A. Ahmed, Stephanie A. Pangas Reproductive aging is associated with declining fertility and increasing inflammation, though these events are not well understood. An exciting new study in PLOS Biology utilizes cutting-edge technologies to characterize the role of multinucleated giant cells in ovarian aging. Reproductive aging is associated with declining fertility and increasing inflammation, though these events are not well understood. This Primer discusses a new study that uses cutting-edge technologies to characterize the role of multinucleated giant cells in ovarian aging.

Jun 24, 2025 - 21:20
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The aging ovary stands on the shoulders of giant multinucleated cells

by Avery A. Ahmed, Stephanie A. Pangas Reproductive aging is associated with declining fertility and increasing inflammation, though these events are not well understood. An exciting new study in PLOS Biology utilizes cutting-edge technologies to characterize the role of multinucleated giant cells in ovarian aging. Reproductive aging is associated with declining fertility and increasing inflammation, though these events are not well understood. This Primer discusses a new study that uses cutting-edge technologies to characterize the role of multinucleated giant cells in ovarian aging.