Immune control of metastatic cancer at the edge of the central nervous system
Nature, Published online: 14 May 2025; doi:10.1038/d41586-025-01470-9Leptomeningeal metastasis is a deadly consequence of cancer that creates an unusually inflamed environment around the brain and spinal cord. One of the inflammatory signalling molecules found in cerebrospinal fluid, interferon-γ, induces an antitumour immune response through an unexpected series of cell–cell interactions.
Nature, Published online: 14 May 2025; doi:10.1038/d41586-025-01470-9Leptomeningeal metastasis is a deadly consequence of cancer that creates an unusually inflamed environment around the brain and spinal cord. One of the inflammatory signalling molecules found in cerebrospinal fluid, interferon-γ, induces an antitumour immune response through an unexpected series of cell–cell interactions.
