Targeting symbionts by apolipoprotein L proteins modulates gut immunity
Nature, Published online: 14 May 2025; doi:10.1038/s41586-025-08990-4APOL9a/b proteins coat mouse intestinal bacteria with high specificity, and genetic abolition of ceramide-1-phosphate synthesis pathways in the symbiote Bacteroides thetaiotaomicron significantly decreases this binding of APOL9a/b to the bacterium.
Nature, Published online: 14 May 2025; doi:10.1038/s41586-025-08990-4APOL9a/b proteins coat mouse intestinal bacteria with high specificity, and genetic abolition of ceramide-1-phosphate synthesis pathways in the symbiote Bacteroides thetaiotaomicron significantly decreases this binding of APOL9a/b to the bacterium.
