Solid phase transitions as a solution to the genome folding paradox
Nature, Published online: 14 May 2025; doi:10.1038/s41586-025-09043-6In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rather than liquid, phase properties.

Nature, Published online: 14 May 2025; doi:10.1038/s41586-025-09043-6In vitro reconstitution and in vivo live-cell imaging of LHX2–EBF1–LDB1 enhancer hubs in olfactory sensory neurons reveals that these transcription factors form condensates with solid, rather than liquid, phase properties.