Radiation-induced amphiregulin drives tumour metastasis

Nature, Published online: 14 May 2025; doi:10.1038/s41586-025-08994-0Radiotherapy induces expression of the EGFR ligand amphiregulin, which promotes metastasis growth at remote sites in mouse models and human patients by shifting myeloid cells towards an immunosuppressive state.

May 14, 2025 - 16:46
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Radiation-induced amphiregulin drives tumour metastasis

Nature, Published online: 14 May 2025; doi:10.1038/s41586-025-08994-0Radiotherapy induces expression of the EGFR ligand amphiregulin, which promotes metastasis growth at remote sites in mouse models and human patients by shifting myeloid cells towards an immunosuppressive state.