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Nuances in the control of separase activity between mitosis and meiosis
by Martin Anger Mammalian oocytes are prone to chromosome segregation errors, which frequently lead into aneuploidy and pregnancy loss. A new study in PLOS Biology addresses the role of the Mad2/SGO2 complex in the control of separase activity in these cells during meiosis. Separase plays an important role in cleaving cohesin complexes that hold chromosomes together during cell division. This Primer explores a new study in PLOS Biology showing that control of separase activity is accomplished by cyclin B/CDK1 and securin, and does not involve SGO2 as reported in somatic cells.
by Martin Anger Mammalian oocytes are prone to chromosome segregation errors, which frequently lead into aneuploidy and pregnancy loss. A new study in PLOS Biology addresses the role of the Mad2/SGO2 complex in the control of separase activity in these cells during meiosis. Separase plays an important role in cleaving cohesin complexes that hold chromosomes together during cell division. This Primer explores a new study in PLOS Biology showing that control of separase activity is accomplished by cyclin B/CDK1 and securin, and does not involve SGO2 as reported in somatic cells.
