Morning vs Nighttime Hypertension Medication Dosing

Normal circadian rhythm of blood pressure (BP), defined as a BP decline of 10% to 20% at night, is an important predictor of cardiovascular health and an indicator of cardiovascular disease (CVD) risk when absent. For treatment of hypertension, it has been standard practice to dose antihypertensive medications in the morning to address higher daytime BP levels; the effects of altering timing of drug dosing on circadian rhythm have not been convincingly delineated.