CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells

Nature, Published online: 04 June 2025; doi:10.1038/s41586-025-09087-8The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.

Jun 4, 2025 - 17:10
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CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells

Nature, Published online: 04 June 2025; doi:10.1038/s41586-025-09087-8The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeric antigen receptors.