Iron deficiency in pregnant mice causes XY embryos to develop with female characteristics

Nature, Published online: 04 June 2025; doi:10.1038/d41586-025-01456-7In mice, a lack of maternal iron impairs an iron-dependent enzyme that activates the male sex-determining gene, causing some XY embryos to develop ovaries.

Jun 4, 2025 - 17:10
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Iron deficiency in pregnant mice causes XY embryos to develop with female characteristics

Nature, Published online: 04 June 2025; doi:10.1038/d41586-025-01456-7In mice, a lack of maternal iron impairs an iron-dependent enzyme that activates the male sex-determining gene, causing some XY embryos to develop ovaries.