Unravelling cysteine-deficiency-associated rapid weight loss
Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-08996-yConditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.
Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-08996-yConditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.
