PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-09017-8PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-high cells preferring the lung.
Nature, Published online: 21 May 2025; doi:10.1038/s41586-025-09017-8PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-high cells preferring the lung.
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