Opinion: How physicians like me are grappling with requests for unvaccinated donor blood
As a transfusion medicine physician, Jeremy W. Jacobs has increasingly faced requests for “unvaccinated donor blood.” So he and colleagues looked closer at what the data say.

As a transfusion medicine physician, I have encountered increasing requests for blood from Covid-19 unvaccinated donors or directed donations based on personal beliefs. In one case, a patient refused transfusion from the standard donor pool — insisting on receiving only blood from unvaccinated individuals — and ultimately experienced severe complications during surgery due to delayed transfusion, despite multiple consults and clear explanations that vaccination status has no impact on blood safety.
These encounters underscore the growing challenge of misinformation and the ethical tension between respecting autonomy and protecting patients from preventable harm.