Bioprinting Perfusable and Vascularized Skeletal Muscle Flaps for the Treatment of Volumetric Muscle Loss (Adv. Healthcare Mater. 13/2025)

Tissue Engineering

In article 2404542, Shulamit Levenberg and co-workers present multimodal bioprinting as an innovative approach for fabricating vascularized muscle flaps to treat volumetric muscle loss (VML). These flaps incorporate a 3D-printed macrovessel within vascularized bioprinted muscle tissue, promoting tissue integration, viability, and functional recovery. Using human-derived cells, this method lays the foundation for patient-specific muscle printing for advanced soft tissue reconstruction.