TIR domains produce histidine-ADPR as an immune signal in bacteria
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08930-2In response to phage infection, the Toll/interleukin-1 receptor (TIR) domain protein ThsB of the type II Thoeris defence system produces histidine conjugated to ADP-ribose, which stimulates bacterial defence by interacting with the Macro domain of the ThsA membrane effector protein.
Nature, Published online: 30 April 2025; doi:10.1038/s41586-025-08930-2In response to phage infection, the Toll/interleukin-1 receptor (TIR) domain protein ThsB of the type II Thoeris defence system produces histidine conjugated to ADP-ribose, which stimulates bacterial defence by interacting with the Macro domain of the ThsA membrane effector protein.
