Dual‐Functional Hafnium Oxide Nanoplatform Combining High‐Z Radiosensitization With Bcl‐2 Gene Silencing for Enhanced Cancer Radiotherapy (Adv. Healthcare Mater. 15/2025)

Cancer Radiotherapy

In article 2404819, Wooram Park and co-workers develop a dual-functional hafnium oxide nanoplatform that synergistically enhances radiotherapy efficacy through high-Z radiosensitization and Bcl-2 gene silencing. This innovative approach effectively increases radiation-induced DNA damage while simultaneously suppressing radioresistance mechanisms, resulting in significant tumor growth inhibition with favorable biocompatibility in a murine colon cancer model.