Condensate dynamics at the synapse: Phase separation tunes presynaptic function
by Janine Lützkendorf, Stephan J. Sigrist A new study in PLOS Biology shows that Liprin-α and RIM form condensates which not only scaffold presynaptic protein architectures but also fine-tune vesicle priming and release dynamics. Liprin-α and RIM form liquid phase-separated condensates that organize presynaptic architecture and fine-tune neurotransmitter release. This Primer explores a new study in PLOS Biology analysing how these dynamic assemblies shape synaptic fidelity and what their disruption might mean in neurodevelopmental disease.
by Janine Lützkendorf, Stephan J. Sigrist A new study in PLOS Biology shows that Liprin-α and RIM form condensates which not only scaffold presynaptic protein architectures but also fine-tune vesicle priming and release dynamics. Liprin-α and RIM form liquid phase-separated condensates that organize presynaptic architecture and fine-tune neurotransmitter release. This Primer explores a new study in PLOS Biology analysing how these dynamic assemblies shape synaptic fidelity and what their disruption might mean in neurodevelopmental disease.
