[Comment] The changing spectrum of cardiovascular diseases

Advances in cardiovascular disease prevention are often hailed as one of the major public health accomplishments of the past 50 years. The progress achieved is rooted in efforts challenging the inevitability of vascular events, which led to the discovery of modifiable risk factors and systematic approaches to prevent population exposure. These prevention efforts have led to steep reductions in premature vascular mortality and morbidity in many parts of the world since the 1960s.1–3 However, this downward trend seems to have reached a plateau or even reversed in several high-income countries.