An In Situ Curing, Shear‐Responsive Biomaterial Designed for Durable Embolization of Microvasculature (Adv. Healthcare Mater. 15/2025)

Biomaterials

NeoCast is a shear-thinning, solvent-free, non-adhesive liquid embolic. When injected into vasculature, shear forces disrupt particle interactions and drive NeoCast into the distal vessels (top vessel). As the vessels fill and shear reduces, the particle interactions resume; the material coalesces and fills the proximal vessels (middle vessel). NeoCast then crosslinks into a solid elastomer, ensuring durable occlusion (bottom vessel). More details can be found in article 2404011 by Upma Sharma and co-workers.